Calley is a Senior Advisor at the White House, focusing on healthcare and nutrition policy.

He is the co-author with his sister, Dr. Casey Means, of Good Energy: The Surprising Connection Between Metabolism and Limitless Health, which debuted at #1 on the NYTimes and Amazon lists – and has sold over 1 million copies. He co-founded Truemed, a company which has helped over 500,000 people use medical spending on food and exercise to reverse chronic disease. He has started nonprofits that have raised millions of dollars for research and advocacy to reverse chronic disease.

He has appeared on podcasts such as Joe Rogan, Skinny Confidential, Megyn Kelly, and Tucker Carlson (where the episode with his sister was the most shared podcast of 2024). He is a graduate of Stanford and Harvard Business School.